Originally, it served as the University's first central meeting place and was used for lectures. St Mary's also holds historical significance as the site of the 1555 trial of the Oxford Martyrs, where bishops Latimer and Ridley, along with Archbishop Cranmer, were tried for heresy during the reign of Mary I. All three were subsequently burned at the stake on Broad Street.

The church features remarkable Gothic architecture, 15th-century stained glass windows, a Baroque porch, and a 13th-century porch. Visitors can ascend the church’s tower, which stands at 128 feet (£4) and offers excellent views of the adjacent Radcliffe Camera and the city of Oxford. The climb involves navigating a spiral staircase with over 120 steps, which can be challenging for some; however, the panoramic views of Oxford’s spires, rooftops, and landmarks are well worth the effort.

St Mary’s is open to visitors throughout the year from 9:00 am to 5:00 pm. Admission to the church itself is free, while tickets to ascend the tower are priced at £6. This historic site provides a unique glimpse into Oxford’s rich heritage and offers an unparalleled vantage point to appreciate the city's architectural splendor.

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